Professional Background

Dr. Dina L. Newman

Assistant Professor, Department of Biological Sciences, Rochester Institute of Technology, 2008-present

Research Assistant Professor, Department of Biological Sciences, Rochester Institute of Technology, 2003-2008
- Grants from NIH/NIA (2006-present), the American Hearing Research Foundation (2005, 2006) and the National Organization for Hearing Research (2004)
- Mentored >25 undergraduate students on research projects
- Instructor for laboratory sections of various courses
- Course development for Introduction to Biology with Dr. Harvey Pough and Dr. Kate Wright
- see homepage for current research

Research Professional, Department of Human Genetics, The University of Chicago, 2001-2003
Post-doc, same lab, 1998-2000
- Worked with Dr. Carole Ober on complex trait genetics
- Completed "Genetic Approaches to Complex Heart, Lung and Blood Diseases," a course on complex disease genetics sponsored by NIH/NHLBI at Jackson Laboratories in Bar Harbor, ME (1998)
- Teaching Assistant for a human genetics course
- Grant to study genetics of cardiovascular disease in a founder population, the Hutterites (also see Hutterite Brethren homepage).
- Worked on genetics of asthma and atopy in the Hutterites and other populations

Ph.D., Committee on Genetics, The University of Chicago, 1998
- Dissertation with Dr. James Shapiro on bacterial colony development: "Iron-dependent differentially regulated expression of a fiu-lacZ fusion in Escherichia coli colonies."

M.S., Department of Biochemistry and Molecular Biology, The University of Chicago, 1993
- Teaching Assistant for a general biology course and a biochemistry course

B.S. with honors in Biological Sciences, Cornell University, 1991
- Concentration in Genetics and Development
- Hughes Scholars Program (HHMI) at Cornell
- Honors thesis with Dr. Antonie Blackler on frog development: "Effect of salt on aging of Xenopus laevis oocytes."
- Research Assistant during the summers of 1988 and 1989 with Dr. Kenneth Zamkoff at SUNY Upstate Medical Center
- Undergraduate Teaching Assistant for a biochemistry laboratory course (2 semesters)

Professional Membership:
The American Society of Human Genetics, 2001-present
The Association for Research in Otolaryngology, 2004-present
Council on Undergraduate Research, 2004-present
Sigma Xi, 2005-present

Publications:

Chan A*, Newman DL*, Shon AM, Schneider DH, Kuldanek S, Ober C (2006). Variation in the Type I interferon gene cluster on 9p21 influences susceptibility to asthma and atopy. Genes Immun 7(2):169-178. *These authors contributed equally.

Weiss LA, Veenstra-VanderWeele J, Newman DL, Kim SJ, Dytch H, McPeek MS, Cheng S, Ober C, Cook EH, Abney M. Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin. Eur J Hum Genet. 2004 Aug; 12(11):949-54.

Newman DL, Hoffjan S, Bourgain C, Abney M, Nicolae RI, Profits ET, Grow MA, Walker K, Steiner L, Parry R, Reynolds R, McPeek MS, Cheng S, Ober C. Are common disease susceptibility alleles the same in outbred and founder populations? Eur J Hum Genet. 2004 Jul;12(7):584-90.

Hoffjan S, Ostrovnaja I, Nicolae D, Newman DL, Nicolae R, Gangnon R, Steiner L, Walker K, Reynolds R, Greene D, Mirel D, Gern JE, Lemanske RF Jr, Ober C. Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy. J Allergy Clin Immunol. 2004 Mar;113(3):511-8.

Bourgain C, Hoffjan S, Nicolae R, Newman D, Steiner L, Walker K, Reynolds R, Ober C, McPeek MS. Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus. Am J Hum Genet. 2003 Sep;73(3):612-26.

Newman DL, Abney M, Dytch H, Parry R, McPeek MS, Ober C. Major loci influencing serum triglyceride levels on 2q14 and 9p21 localized by homozygosity-by-descent mapping in a large Hutterite pedigree. Hum Mol Genet. 2003 Jan 15;12(2):137-44.

Newman DL, Abney M, McPeek MS, Ober C, Cox NJ. The importance of genealogy in determining genetic associations with complex traits. Am J Hum Genet. 2001 Nov;69(5):1146-8.

Ober C, Leavitt SA, Tsalenko A, Howard TD, Hoki DM, Daniel R, Newman DL, Wu X, Parry R, Lester LA, Solway J, Blumenthal M, King RA, Xu J, Meyers DA, Bleecker ER, Cox NJ. Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations. Am J Hum Genet. 2000 Feb;66(2):517-26.

Ober C, Tsalenko A, Willadsen S, Newman D, Daniel R, Wu X, Andal J, Hoki D, Schneider D, True K, Schou C, Parry R, Cox N. Genome-wide screen for atopy susceptibility alleles in the Hutterites. Clin Exp Allergy. 1999 Dec;29 Suppl 4:11-5.

Newman DL, Shapiro JA. Differential fiu-lacZ fusion regulation linked to Escherichia coli colony development. Mol Microbiol. 1999 Jul;33(1):18-32.

Abstracts (Presentations at Meetings):

Newman DL, Skuse G, Wright K (2008). Inquiry Based Learning in Biology. Empire State Association of Two Year College Biologists, Ithaca, NY.

Libby P, Koplitz M, Mapes F, Frisina ST, Eddins DA, Frisina RD, Newman DL (2008). Connexin gene variants are not common causes of presbycusis in European Americans. Association for Research in Otolaryngology, 31st Annual Midwinter Meeting. Phoenix, AZ.

Souza A, Braganza A, Parker B, Frisina RD, Newman DL (2007). Examination of the mitochondrial genome for causes of presbycusis. Rochester Academy of Science Fall Scientific Paper Session. Geneseo, NY. Oral presentation by an RIT undergraduate student.

Aghayere O, Abdullah N, Paee F, Braganza A, Souza A, Parker B, Frisina RD, Newman DL (2007). Investigation of the mitochondrial genome for variants that protect against hearing loss. Rochester Academy of Science Fall Scientific Paper Session. Geneseo, NY. Poster presentation by RIT undergraduate students.

Libby P, Frisina RD, Newman DL (2007). Promoter region variation in GJA1 is not associated with age-related hearing loss. Rochester Academy of Science Fall Scientific Paper Session. Geneseo, NY. Poster presentation by an RIT undergraduate student.

Parker BS, Braganza AC, Souza A, Newman DL (2007). Haplogroup-specific SNP discovery in the mitochondrial genome for the investigation of the causes of presbycusis. 2007 Annual Biomedical Research Conference for Minority Students. Austin, TX. Poster presentation by a student from Monroe Community College.

Stevens EL, Sanchez RI, Osier MV, Newman DL (2007). Construction of a SNP-Associated Mitochondrial Haplogroup Database. 57th Annual Meeting of the American Society of Human Genetics. San Diego, CA. Poster presentation by an RIT undergraduate student.

Souza A, Braganza A, Parker B, Newman DL (2007). Examination of the mitochondrial genome for the cause of presbycusis. 16th Annual RIT Undergraduate Research Symposium, Rochester, NY. Oral presentation by an RIT undergraduate.

Stevens EL, Newman DL (2007). Construction of a SNP-associated mitochondrial haplogroup database. 16th Annual RIT Undergraduate Research Symposium, Rochester, NY. Oral presentation by an RIT undergraduate.

Ismail A, Lebowitz R, Newman DL (2007). Investigation of connexin genes GJB2 and GJB6 for potential involvement in the development of presbycusis. Northeast Regional Sigma Xi Conference. Ithaca, NY. Poster presentation by an RIT undergraduate student.

Newman DL, Ramón S, Braganza AC, Sanchez R, Frisina ST, Mapes F, Parody R, Frisina DR, Eddins DA, Osier MV, Frisina RD (2007). Evidence for mitochondrially inherited factors in human presbycusis. Association for Research in Otolaryngology, 30th Annual Midwinter Research Meeting. Denver, CO.

Ramón S, Braganza AC, Mapes FM, Frisina ST, Frisina RD, Frisina DR, Eddins DA, Newman DL (2006). European mitochondrial haplogroups exhibit differential risk of developing presbycusis. 56th Annual Meeting of the American Society for Human Genetics. New Orleans, LA. Poster presentation by an RIT undergraduate student.

Sanchez R, Parody R, Newman DL, Osier MV (2006). Automated analysis to determine the association of human mitochondrial haplogroups with presbycusis. 15th Annual RIT Undergraduate Research Symposium, Rochester, NY. Oral presentation by RIT undergrad, won prize.

Susa RKM, Spony T, Newman DL (2005). Polymorphisms in GJA1 potentially associated with presbycusis. Sigma Xi Annual Meeting and Student Research Conference, Seattle, WA. Poster presentation by RIT undergrads RKMS & TS, won blue ribbon.

Newman DL, Raish KD, Edsall LE, Witkowski CM, Eddins DA, Frisina DR, Shipman PA, Osier MV (2005). Cluster Rank Analysis provides evidence for mitochondrial inheritance of presbycusis. 55th Annual Meeting of the American Society for Human Genetics. Salt Lake City, UT.

Brady B, Raish K, Frisina DR, Newman DL (2005). Examination of the mitochondrial genome for presbycusis markers. 14th Annual RIT Undergraduate Research Symposium, Rochester, NY. Platform presentation by RIT undergrad, won prize.

Taslimi A, D'Souza M, Zhu X, Lynch-Erhardt M, Brooks A, Frisina RD, Newman DL (2005). Gja1 gene expression in the CBA mouse cochlea decreases with age. Association for Research in Otolaryngology, 28th Annual Midwinter Research Meeting. New Orleans, LA. Poster presentation by AT, an RIT undergraduate student.

De Vitry RP, Middlebrooks CD, Raish KD, Newman DL (2004). Investigating polymorphisms in the human mitochondrial genome for association with age-related hearing loss. Rochester Academy of Science 31st Annual Paper Session. Rochester, NY. Poster presentation by RPD, an RIT undergraduate student.

Susa, RM, Raish KD, Newman DL (2004). Detecting single-nucleotide polymorphisms in GJA1, a candidate gene for age-related hearing loss. Rochester Academy of Science 31st Annual Paper Session. Rochester, NY. Platform presentation by RMS, an RIT undergraduate student.

Wells, EM, Raish, KD, Newman DL (2004). Examination of GJB3 for polymorphisms in presbycusic subjects. Rochester Academy of Science 31st Annual Paper Session. Rochester, NY. Poster presentation by EMW, an RIT undergraduate student.

De Vitry RP, Raish KD, Newman DL (2004) Detection of polymorphisms in the human mitochondrial genome of subjects afflicted with age-related hearing loss. 13th Annual RIT Undergraduate Research Symposium. Rochester, NY. Platform presentation by RPD, an RIT undergraduate student.

Weiss L, Veenstra-VanderWeele J, Abney M, Newman D, Dytch H, McPeek MS, Cheng S, Cook Jr. E, Ober C (2003) Genome-wide association mapping in a founder population identifies ITGB3 as a QTL for whole-blood serotonin levels. 53rd Annual Meeting of the American Society of Human Genetics. Los Angeles, CA. Platform presentation by LW. [Am J Hum Genet 73(5) Suppl:178.]

Chan A, Newman D, Ober C (2003) Positional cloning of asthma/atopy genes in the interferon gene cluster. 53rd Annual Meeting of the American Society of Human Genetics. Los Angeles, CA. Platform presentation by AC. [Am J Hum Genet 73(5) Suppl:209.]

Tan Z, Schneider D, Newman D, Stanaker R, Ober C (2003) Ankyrin and SOCS box containing gene 2 in a linked region on 14q32 is associated with asthma and brochial hyperresponsiveness in the Hutterites. 53rd Annual Meeting of the American Society of Human Genetics. Los Angeles, CA. [Am J Hum Genet 73(5) Suppl:486.]

Newman DL, Nicolae D, Colilla S, Nicolae R, Howard TD, Barnes KC, Blumenthal MN, Beaty TH, Rich SS, King RA, Bleecker ER, Cox NJ, Mirel DB, Ober C and the Collaborative Study on the Genetics of Asthma (2002). Gene-gene and gene-environment interactions in the IL-4/IL-13 pathway in the development of asthma. 52nd Annual Meeting of the American Society of Human Genetics. Baltimore, MD. Platform presentation by DLN. [Am J Hum Genet 71(4) Suppl:208.]

Bourgain C, Newman D, Ober C and McPeek MS (2002). Performing classical statistical genetic tests in founder populations. 52nd Annual Meeting of the American Society of Human Genetics. Baltimore, MD. Platform presentation by CB. [Am J Hum Genet 71(4) Suppl:177.]

Newman DL, Abney M, McPeek MS, Dytch H, Grow MA, Silbergleit AS, Carlson C, Scanu AM, Cheng S, Ober C (2001). Associations between 65 polymorphisms in 36 candidate genes and cardiovascular disease-related phenotypes. 51st Annual Meeting of the American Society of Human Genetics. San Diego, CA. [Am J Hum Genet 69(4) Suppl:501.]

Newman DL, Kogut PC, Solway J, Ober C (2001). Protein phosphatase (PPP) gene family is associated with asthma and atopy in the Hutterites. 97th International Conference of the American Thoracic Society. San Francisco, CA. Platform presentation by DLN.

Newman DL, McPeek MS, Abney M, Dytch H, Scanu AM, Parry R and Ober C (2000). Genome-wide screens for quantitative trait loci (QTLs) influencing lipid levels in a founder population. 50th Annual Meeting of the American Society of Human Genetics. Philadelphia, PA. [Am J Hum Genet 67(4) Suppl 2:324.]

Newman DL and Ober C (2000). Sequence variation underlying DHPLC patterns. DNA 2000: International Symposium on the State-of-the-Art in Genetic Analysis. Boston, MA.

Newman DL, Tsalenko A, Cox NJ, and Ober C (1999). NIDDM1 is associated with diabetes and body fat distribution in the Hutterites. 49th Annual Meeting of the American Society of Human Genetics. San Francisco, CA. [Am J Hum Genet 65(4) Suppl:A437.]

Newman DL and Shapiro JA (1995). Coordinated regulation in E. coli colony development. 24th Annual Steenbock Symposium on Behavior and Signaling in Microorganisms. Madison, WI.