A resin is an insoluble polymer backbone for the stationary phase. Polystyrene resins are often used as the backbone for separations of small molecules and ions, because the polystyrene is chemically resistant to most solvents and can hold a high density of a bonded stationary phase. Resin-based stationary phases tend to denature proteins due to the high charge density. Therefore, most protein separations are done with stationary phases attached to hydrophilic gels.

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Stationary Phase