Our group is interested in two different research areas. DQA is a drug quality assurance project focussing on developing new analytical methods to validate the quality of critical medicines such as malarial medication. This work is part of the RIT-RGH Alliance and conducted in collaboration with the South Dakota School of Mines and Technology. Our group is also engaged in Inorganic Synthetic Chemistry particularly the development of electrical or magnetic functional nano-materials designed for production scale printing (Functional Printing). This work is done in collaboration with the Brinkman Laboratory, Industrial Systems Management in the College of Engineering. Undergraduate researchers drive this work, and all are welcome to inquire.
CAMM is is a colorimetric test that indicates the presence and dose of multiple malaria medications. It is simple to use, fast (minutes) and low cost (cents per test) .
Plasmodium falciparum (malaria) infects between 200 and 500 million people per year worldwide. Nearly one million deaths per year occur, mostly in children under five. Fortunately, there is an effective therapy that is successful at treating the disease. Unfortunately, there are up to 70% counterfeit medications delivered to patient. The counterfeit manufacturers duplicate the pills to exacting color, shape, size, demarcation, blister packaging, etc. There are many other common counterfeits that need to have simple means to establish their authenticity. In western European countries consumers spent $14 billion (USD) on counterfeit medications. Worldwide, counterfeit medications sold are worth $75 billion (USD).
This research relates to methods for authenticating medications and/or quantifying the active ingredients for malaria medications. Our testing methods have many advantages over existing technology. For example, our testing methods provide unmistakably clear results that can be implemented and interpreted without special training, anywhere in the world. Further, our testing methods offer both quantitative and qualitative results. The methods yield different colors where the actual color indicates the presence of the active ingredient, and the intensity of the color indicates the concentration of the active ingredient. The testing methods are very inexpensive to produce, manufacture, and employ. They are simple chemical test that requires no power, batteries, or equipment of any sort.
Research is directed toward the deposition of functional nanomaterial and nanomaterial composites using the production scale printing processes. Of particular interest are metal oxide compositions, Lead Zironium Titanate (Pb(Zr1-XTix)O3) and Yttrium Stabilized Zirconium (YSZ) materials. These materials are structurally designed and combined to produce a wide variety of sensors and actuators for aerospace and medical applications, for example. In collaboration with RIT Engineering, we are developing new device designs and strategies using a variety of non-impact printing processes. Unique to our research program, is that these printing platforms are production scale devices; highlighting that, our goal is to enable technology translation from the laboratory to manufacture. Undergraduates conducting research in our collaboration rich environment, will be able to observe how diverse multidisciplinary teams work together to produce novel technologies that can be adopted to the marketplace.
Possible Student Projects Include:
- Lead-free Perovskite Planar Heterojunction Fabrication Using Aerosol Jet Printing to Produce Flexible and Efficient Solar Cell Devices
- PZT Sensor Development on Flexible Ceramic YSZ Substrates
- Functionalizing Conformal Surfaces with Active Nanomaterials Using Multi-axis Deposition Strategies.
DQA - South Dakota School of Mines and Technology
Functional Printing - RIT
Recent Group News
Tyler Hess and Elizabeth May presented their research on PZT sol gel deposition using the Aerosol Jet Printing Process at the 2014 RIT Undergraduate Research Symposium.